Straumann^® Emdogain - the cellular process

Effects at the cellular level.

By mimicking the biological processes of natural tooth development, Straumann^® Emdogain forms an insoluble three dimensional extra-cellular matrix. This matrix remains on the root surface for 2-4 weeks and allows for the selective colonization, proliferation and differentiation of cells.

Days			Weeks
	The amelogenins form a matrix layer on the root surface. Contact to cells of the healthy part of the desmo-dontium is established.			The cells secrete natural and specific cytokines and autokrine substances, which promote the required proliferation.
	Adduction and proliferation of mesenchymal cells from the healthy part of the desmodontium.			Attraction and differentiation to cementoblasts, begin of formation of the cement matrix in which the desmodontal fibres will be fixed.
Months			One year
	Anchoring of desmodontal fibers in the root surface.			Regeneration of the desmodontium; a new functional attachment has been formed.
	Filling of defect with newly formed desmodontal tissue.
	New alveolar bone grows on the root surface and in the defect gap.